Product Description
Vasoactive intestinal peptide (VIP) is a synthetic 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. It acts as a potent neuromodulator and neurotransmitter in the central and peripheral nervous systems. VIP activates the intracellular cAMP signaling pathway by selectively binding to high-affinity VPAC1 and VPAC2 receptors on the cell surface, thereby regulating local blood flow, smooth muscle tone, and immune system responses.
Product Benefits
Proponents of VIP supplements believe they help alleviate immune overactivation, improve lung airflow, and restore the natural sleep-wake cycle. This is because VIP is an important endogenous signaling molecule—when receptor pathways are balanced, cells can more effectively reduce chronic stress and promote overall system homeostasis.
Circadian Rhythm Regulation: Since the suprachiasmatic nucleus (SCN) is the master control region of the biological clock, researchers wanted to understand whether increasing vasoactive intestinal peptide (VIP) levels could improve cellular synchrony and repair sleep disorders.
Immune system regulation: Its role in downregulating pro-inflammatory cytokines and guiding the immune response towards tolerance has sparked research interest in models of autoimmune diseases, although related clinical studies are still in their early stages.
Gastrointestinal and respiratory health: Because VIP can regulate smooth muscle relaxation and epithelial cell secretion, scientists are investigating its potential link with improving airway patency and protecting mucosal barrier integrity.