Product Description
PE 22-28 is a synthetic heptapeptide with the amino acid sequence GVSWGLR, a shortened analog of the endogenous sorting protein propeptide spadin. It is the smallest known functional fragment that still effectively inhibits the K2P2.1/TREK-1 channel, a member of the potassium channel subfamily K. Neurochemical assessments show that PE 22-28 selectively blocks TREK-1-mediated background potassium ion flow with high specificity and nanomolar affinity (IC₅₀ = 0.12 nM). This targeted blockade modulates cell membrane potential and regulates downstream signaling pathways involved in neuronal excitability, neuroplasticity, and synaptic transmission in mammalian cortical and hippocampal structures.
Product Benefits
Proponents of PE 22-28 supplementation believe it helps enhance cognitive resilience and accelerate neural repair. This is because it is a highly selective TREK-1 potassium channel inhibitor—when these channels are modulated, cells may more effectively promote neurogenesis and balance neurotransmitter activity.
Synapses and Cognitive Plasticity: Since hippocampal neurons are crucial for memory and learning, researchers are eager to understand whether supporting neuroplasticity by blocking TREK-1 can help maintain cellular function and memory in the central nervous system.
Neurological Diseases: The role of PE 22-28 in inducing brain-derived neurotrophic factor (BDNF) has drawn attention to diseases such as major depressive disorder and ischemic neurodegenerative diseases, although related research is still in its early stages.
Neuroprotective Health: Because the regulation of TREK-1 is involved in maintaining neuronal membrane potential, scientists are investigating its potential link with protecting brain tissue from oxidative stress and atrophy caused by chronic stress.