Product Description
Humanin is an endogenous, mitochondrial-derived peptide (MDP) comprised of 24 amino acids that functions as a highly potent cytoprotective and anti-apoptotic rescue factor. First discovered in 2001 for its ability to preserve neuronal viability against Alzheimer’s disease-associated toxicity, it has since become a widely researched biochemical tool for investigating age-related disorders, metabolic cellular stress, and longevity.
Product benefits
Inhibits Programmed Cell Death (Apoptosis): Humanin directly binds to and neutralizes pro-apoptotic proteins like Bax and tBid. This action prevents mitochondrial outer membrane permeabilization, blocking the cascade that leads to cell suicide.
Reduces Oxidative Stress: The peptide lowers intracellular reactive oxygen species (ROS) and harmful malondialdehyde levels. Simultaneously, it upregulates vital endogenous antioxidants like superoxide dismutase (SOD) and glutathione.
Restores Mitochondrial Function: It helps maintain mitochondrial membrane potential, protects mitochondrial DNA from degradation, and ensures efficient ATP production under cellular stress.
Suppresses Chronic Inflammation: Humanin downregulates pro-inflammatory cytokines (such as TNF-α, IL-6, and IL-1β) by modulating the NF-κB and JAK2/STAT3 signaling pathways.