Ara-290

Product Description

ARA-290 (Cibinetide) is a synthetic 11-amino-acid peptide derived from the helix-B surface region of erythropoietin (EPO). It is engineered as a highly selective agonist for the innate repair receptor (IRR), which is a heterodimer complex composed of the erythropoietin receptor and the beta-common receptor (EPOR/CD131). Unlike full-length erythropoietin, ARA-290 isolates tissue-protective pathways without interacting with the homodimeric EPO receptor responsible for erythropoiesis. In laboratory and physiological settings, its binding initiates local protective signaling cascades that counteract cellular stress and overactivated tissue inflammation.

Product benefits

Neuropathic Support & Pain Relief: Because peripheral nerve signaling relies on intact axon pathways, researchers want to understand whether activating the IRR complex via ARA-290 can alleviate neuropathic hypersensitivity and protect small nerve fibers from progressive structural damage. 

Tissue-Protective Resilience: The role of ARA-290 in downregulating pro-inflammatory cytokines like TNF-α and IL-6 has sparked interest in ischemia-reperfusion injury and severe tissue trauma models, although related human clinical trials remain constrained to specific rare indications.

Metabolic Organ Health: Because chronic cellular stress compromises vascular and endocrine systems, scientists are investigating its potential links to improving metabolic control, adjusting lipid dynamics, and shielding delicate kidney cells from toxicity.

ARA-290 Specifications