Product Description
Dermorphin is a naturally occurring heptapeptide and a potent, selective μ-opioid receptor (MOR) agonist. Originally isolated from the skin secretions of the South American frog (Leaf Frog), it contains a unique D-amino acid (D-alanine) in its sequence, which is extremely rare in multicellular organisms. This unique molecular structure allows Dermorphin to effectively cross the blood-brain barrier and makes it highly resistant to metabolic degradation by endogenous peptidases. In scientific research, it is a potent neuromodulator and an important tool for studying pain pathways and opioid receptor dynamics.
Product Advantages
Dermorphin’s proponents in biochemical research utilize its unique high affinity properties to map pain transmission, study neural pathways, and assess receptor downregulation. Due to its excellent stability, it is a valuable reference compound for understanding neural signal transduction and receptor interactions within damaged or simulated pain networks.
Extremely potent analgesic activity: In laboratory models, Dermorphin exhibits analgesic potency several times that of morphine, making it a key benchmark for evaluating the efficacy of novel central nervous system (CNS) compounds.
Antipeptidase activity: Due to its unique D-Ala structure, this peptide remains highly stable in biological fluids, allowing researchers to study sustained opioid receptor activation without interference from rapid enzymatic degradation.
Targeted receptor selectivity:Dermorphin exhibits extremely high selectivity for μ-opioid receptors, far exceeding that for δ or κ receptors. This provides a precise cellular localization tool for isolating and analyzing specific neurochemical responses and tolerance mechanisms.